Since the events are infrequent, data can be collected by patient report, and/or administrative records (363).

Currently available evidence suggests a role in identifying the phenotype in airways disease, particularly in the identification of corticosteroid responsiveness. Assessment of variations in control of asthma over time.

Retrospective subject-completed data collection forms. There is a poor correlation between change in AQLQJuniper and change in FEV1 (399).

Standardization—the ERS and ATS guidelines for bronchial challenge tests require updating, to include GMP requirements, novel challenge agents, and new aerosol dosing techniques.

Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness. Swiss Study on Air Pollution and Lung Disease in Adults.

Often, categorical cut-points were then applied to the total score, to allow categorization of patients into well-controlled, poorly controlled, and so on. La liste est longue et complexe, tant les ivoiriens sont riches en expressions de ce genre ! Enright PL, Lebowitz MD, Cockroft DW. FeNO is a reasonably robust estimate of the presence of eosinophilic airway inflammation across a wide range of patients differing in diagnosis (294). van den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koeter GH, Kauffman HF, Postma DS.

The ACQ (158) was developed by Juniper and coworkers for assessing asthma control in clinical trials and clinical practice. Spirometry (pre-bronchodilator and post-bronchodilator) should be measured at the baseline examination of most asthma clinical trials, for all study participants aged 6 years or more. A vous de pouvoir redresser la barre pour prouver le contraire. Airway hyperresponsiveness. Aholé , c'est cool en tout cas, on completera ensemble la prochaine fois alors, Tchiéééé!

In: Haynes RB, Taylor DW, Sackett DL, editors. Sullivan SD, Wenzel SE, Bresnahan BW, Zheng B, Lee JH, Pritchard M, Kamath TV, Weiss ST, TENOR Study Group.

Sources of variation in FEV1. Composite scores should be relatively simple and easy to administer. Indeed, improvement in symptoms using, for example, LABA therapy, may occur without any change in pre-bronchodilator FEV1 (61).
Recording of data for unscheduled use of secondary health care is relatively easy.

*Baseline characteristics are assessed at the randomization visit, or, for diary measures, during the final 2 wk of run-in.

van Essen-Zandvliet EE, Hughes MD, Waalkens HJ, Duiverman EJ, Pocock SJ, Kerrebijn KF. For example, in a retrospective analysis, Bateman and colleagues showed that patients who achieved well-controlled asthma according to a guideline-based composite measure achieved greater improvements in quality of life than if success in only a single component of asthma control was achieved (227). Senthilselvan A, Lawson JA, Rennie DC, Dosman JA. Defining the end of an exacerbation, particularly if it represents only poor control, is even more challenging.

Covar RA, Spahn JD, Martin RJ, Silkoff PE, Sundstrom DA, Murphy J, Szefler SJ.

Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma. Jones PW.

Schatz M, Mosen DM, Kosinski M, Vollmer WM, Magid DJ, O'Connor E, Zeiger RS. The dose–response curve for ICS plateaus at a low dose, and there is little evidence of an additional effect above 200 μg/day (beclomethasone equivalent) in most patients (278, 279).

Merci du passage, juste une question d'habitudes, après c'est plus simple, Kouadio Blanc "happé" par mes Frères de Koumassi-sicogi, ton article m'a fait délirer deh Schatz M, Zeiger RS, Mosen D, Apter AJ, Vollmer WM, Stibolt TB, Leong A, Johnson MS, Mendoza G, Cook EF. Kunzli N, Ackermann-Liebrich U, Keller R, Perruchoud AP, Schindler C. Variability of FVC and FEV1 due to technician, team, device and subject in an eight centre study: three quality control studies in SAPALDIA.

Employees of pharmaceutical companies and representatives of other companies with a commercial interest in the output of the Task Force were excluded from membership or observer status. Influence of asthma education on asthma severity, quality of life and environmental control.

Data from paper PEF diaries should be interpreted with caution in the analysis of exacerbations, because of the high proportion of retrospectively completed entries (49) (see Diary Data in the Assessment of Asthma Control).

Emerging work on biomarkers suggests that several measures of airway inflammation should be evaluated in a similar way for inclusion in composite control scores.

The forced oscillation technique in clinical practice: methodology, recommendations and future developments. clinic questionnaire or daily diary? The use of reference values may be helpful when using FeNO as a diagnostic test; in this setting, sex, smoking status, and atopy should be taken into account. Compliance with peak expiratory flow monitoring in home management of asthma.

Benefits of immunotherapy with a standardized.
National Heart Lung and Blood Institute National Asthma Education and Prevention Program. The exact relationship between the fractional concentration of exhaled nitric oxide (FeNO) and the underlying pathologic process in asthma remains unclear (292). The time scale of response to ICS has not been adequately addressed; estimates for the time to a measurable effect range from 3 days (321) to 8 weeks (318). In the assessment of treatment effect, airway hyperresponsiveness also serves as a predictor of future risk (see footnote to previous table). Improvement in asthma endpoints when aiming for total control: salmeterol/fluticasone propionate versus fluticasone propionate alone. Jaeschke R, Guyatt GH, Keller J, Singer J. Interpreting changes in quality-of-life score in N of 1 randomized trials. In asthma, the sputum differential eosinophil count is consistently reduced (two- to sevenfold) by corticosteroids (273, 274) and is increased (up to sevenfold) by allergen challenge (275, 276), before asthma exacerbations (261), and after prednisone reduction (277).

Dose response of inhaled corticosteroids on bronchial hyperresponsiveness: a meta-analysis. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM.

In cross-sectional analysis, for example at study entry, pre-BD FEV1 (% predicted) has been associated with most other measures of asthma control (3, 61, 157). Therefore, AHR is neither a surrogate for clinical symptoms nor for airways inflammation. It depends on the baseline status of the study population (including phenotype), the mechanism of action, dose and duration of treatment, and the properties of the outcome measure itself. The reliability of symptom assessment from questionnaires may be influenced by poor symptom perception and reporting by the child or by the parents.

In one study, higher FeNO with increasing age was also observed in adults (309) but the majority of studies have not confirmed this. Lee TA, Fuhlbrigge AL, Sullivan SD, Finkelstein JA, Inui TS, Lozano P, Weiss KB.


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